Syk-mediated tyrosine phosphorylation of Mule promotes TNF-induced JNK activation and cell death

The transcription factor Miz1 negatively regulates TNF-induced JNK activation and cell death by suppressing TRAF2 K63-polyubiquitination; upon TNF stimulation, the suppression is relieved by Mule/ARF-BP1-mediated Miz1 ubiquitination and subsequent degradation. It is not known how Mule is activated b...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Carrie K., Yang, Yi, Chen, Cong, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729668/
https://www.ncbi.nlm.nih.gov/pubmed/26212014
http://dx.doi.org/10.1038/onc.2015.275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729668/
https://www.ncbi.nlm.nih.gov/pubmed/26212014
http://dx.doi.org/10.1038/onc.2015.275

Ejemplares similares