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Syk-mediated tyrosine phosphorylation of Mule promotes TNF-induced JNK activation and cell death
The transcription factor Miz1 negatively regulates TNF-induced JNK activation and cell death by suppressing TRAF2 K63-polyubiquitination; upon TNF stimulation, the suppression is relieved by Mule/ARF-BP1-mediated Miz1 ubiquitination and subsequent degradation. It is not known how Mule is activated b...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729668/ https://www.ncbi.nlm.nih.gov/pubmed/26212014 http://dx.doi.org/10.1038/onc.2015.275 |