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Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing
Engineered nucleases have transformed biological research and offer great therapeutic potential by enabling the straightforward modification of desired genomic sequences. While many nuclease platforms have proven functional, all can produce unanticipated off-target lesions and have difficulty discri...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729830/ https://www.ncbi.nlm.nih.gov/pubmed/26738816 http://dx.doi.org/10.1038/ncomms10194 |