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Multi-reporter selection for the design of active and more specific zinc-finger nucleases for genome editing

Engineered nucleases have transformed biological research and offer great therapeutic potential by enabling the straightforward modification of desired genomic sequences. While many nuclease platforms have proven functional, all can produce unanticipated off-target lesions and have difficulty discri...

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Detalles Bibliográficos
Autores principales: Oakes, Benjamin L., Xia, Danny F., Rowland, Elizabeth F., Xu, Denise J., Ankoudinova, Irina, Borchardt, Jennifer S., Zhang, Lei, Li, Patrick, Miller, Jeffrey C., Rebar, Edward J., Noyes, Marcus B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729830/
https://www.ncbi.nlm.nih.gov/pubmed/26738816
http://dx.doi.org/10.1038/ncomms10194