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Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2

The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1–Mad2 is crucial for SAC activation. However, the mechanism by which Mad1–Mad2 accumulat...

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Detalles Bibliográficos
Autores principales: Zhou, Haining, Wang, Tianning, Zheng, Tao, Teng, Junlin, Chen, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729865/
https://www.ncbi.nlm.nih.gov/pubmed/26743940
http://dx.doi.org/10.1038/ncomms10151