Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent tissues that elevated glucose, as found in MetS/T2DM, and oligomeric β-amyloid (Aβ) p...

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Detalles Bibliográficos
Autores principales: Akhtar, Mohd Waseem, Sanz-Blasco, Sara, Dolatabadi, Nima, Parker, James, Chon, Kevin, Lee, Michelle S., Soussou, Walid, McKercher, Scott R., Ambasudhan, Rajesh, Nakamura, Tomohiro, Lipton, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729876/
https://www.ncbi.nlm.nih.gov/pubmed/26743041
http://dx.doi.org/10.1038/ncomms10242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729876/
https://www.ncbi.nlm.nih.gov/pubmed/26743041
http://dx.doi.org/10.1038/ncomms10242

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