Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology

It has been suggested that neuronal hyperexcitability contributes to Alzheimer’s disease (AD), so we asked how hyperexcitability develops in a common mouse model of β-amyloid neuropathology - Tg2576 mice. Using video-EEG recordings, we found synchronized, large amplitude potentials resembling interi...

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Detalles Bibliográficos
Autores principales: Kam, Korey, Duffy, Áine M., Moretto, Jillian, LaFrancois, John J., Scharfman, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730189/
https://www.ncbi.nlm.nih.gov/pubmed/26818394
http://dx.doi.org/10.1038/srep20119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730189/
https://www.ncbi.nlm.nih.gov/pubmed/26818394
http://dx.doi.org/10.1038/srep20119

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