Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53

Metformin is known to alleviate hepatosteatosis by inducing 5’ adenosine monophosphate (AMP)-kinase-independent, sirtuin 1 (SIRT1)-mediated autophagy. Dysfunctional mitophagy in response to glucolipotoxicities might play an important role in hepatosteatosis. Here, we investigated the mechanism by wh...

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Detalles Bibliográficos
Autores principales: Song, Young Mi, Lee, Woo Kyung, Lee, Yong-ho, Kang, Eun Seok, Cha, Bong-Soo, Lee, Byung-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730363/
https://www.ncbi.nlm.nih.gov/pubmed/26784190
http://dx.doi.org/10.3390/ijms17010122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730363/
https://www.ncbi.nlm.nih.gov/pubmed/26784190
http://dx.doi.org/10.3390/ijms17010122

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