Hot Spot Mutation in TP53 (R248Q) Causes Oncogenic Gain-of-Function Phenotypes in a Breast Cancer Cell Line Derived from an African American patient

African American (AA) breast cancer patients often have triple negative breast cancer (TNBC) that contains mutations in the TP53 gene. The point mutations at amino acid residues R273 and R248 both result in oncogenic gain-of-function (GOF) phenotypes. Expression of mutant p53 (mtp53) R273H associate...

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Detalles Bibliográficos
Autores principales: Shtraizent, Nataly, Matsui, Hiroshi, Polotskaia, Alla, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730413/
https://www.ncbi.nlm.nih.gov/pubmed/26703669
http://dx.doi.org/10.3390/ijerph13010022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730413/
https://www.ncbi.nlm.nih.gov/pubmed/26703669
http://dx.doi.org/10.3390/ijerph13010022

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