In Vitro and in Vivo Inhibitory Effects of Glycyrrhetinic Acid in Mice and Human Cytochrome P450 3A4

Glycyrrhetinic acid (GA) has been used clinically in the treatment of patients with chronic hepatitis. This study evaluated the effect of GA on the activity of five P450(CYP450) cytochrome enzymes: CYP2A6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4, in human liver microsomes (HLMs) and recombinant cDNA-exp...

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Detalles Bibliográficos
Autores principales: Lv, Qiao-Li, Wang, Gui-Hua, Chen, Shu-Hui, Hu, Lei, Zhang, Xue, Ying, Guo, Qin, Chong-Zhen, Zhou, Hong-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730475/
https://www.ncbi.nlm.nih.gov/pubmed/26712778
http://dx.doi.org/10.3390/ijerph13010084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730475/
https://www.ncbi.nlm.nih.gov/pubmed/26712778
http://dx.doi.org/10.3390/ijerph13010084

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