Chemical synthesis of erythropoietin glycoforms for insights into the relationship between glycosylation pattern and bioactivity

The role of sialyloligosaccharides on the surface of secreted glycoproteins is still unclear because of the difficulty in the preparation of sialylglycoproteins in a homogeneous form. We selected erythropoietin (EPO) as a target molecule and designed an efficient synthetic strategy for the chemical...

Descripción completa

Detalles Bibliográficos
Autores principales: Murakami, Masumi, Kiuchi, Tatsuto, Nishihara, Mika, Tezuka, Katsunari, Okamoto, Ryo, Izumi, Masayuki, Kajihara, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730857/
https://www.ncbi.nlm.nih.gov/pubmed/26824070
http://dx.doi.org/10.1126/sciadv.1500678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730857/
https://www.ncbi.nlm.nih.gov/pubmed/26824070
http://dx.doi.org/10.1126/sciadv.1500678

Ejemplares similares