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Chemical synthesis of erythropoietin glycoforms for insights into the relationship between glycosylation pattern and bioactivity
The role of sialyloligosaccharides on the surface of secreted glycoproteins is still unclear because of the difficulty in the preparation of sialylglycoproteins in a homogeneous form. We selected erythropoietin (EPO) as a target molecule and designed an efficient synthetic strategy for the chemical...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730857/ https://www.ncbi.nlm.nih.gov/pubmed/26824070 http://dx.doi.org/10.1126/sciadv.1500678 |