Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5’-Phosphate Production in E. coli

Recent insights suggest that non-specific and/or promiscuous enzymes are common and active across life. Understanding the role of such enzymes is an important open question in biology. Here we develop a genome-wide method, PROPER, that uses a permissive PSI-BLAST approach to predict promiscuous acti...

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Detalles Bibliográficos
Autores principales: Oberhardt, Matthew A., Zarecki, Raphy, Reshef, Leah, Xia, Fangfang, Duran-Frigola, Miquel, Schreiber, Rachel, Henry, Christopher S., Ben-Tal, Nir, Dwyer, Daniel J., Gophna, Uri, Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731195/
https://www.ncbi.nlm.nih.gov/pubmed/26821166
http://dx.doi.org/10.1371/journal.pcbi.1004705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731195/
https://www.ncbi.nlm.nih.gov/pubmed/26821166
http://dx.doi.org/10.1371/journal.pcbi.1004705

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