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The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: Implications in targeted cancer therapies
The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes underlying development and maintenance of adult tissue homeostasis, including regulation of stem cell self-renewal, cell proliferation, differentiation, and apoptosis. WNTs are secreted lipid-modified glycoprotein...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731283/ https://www.ncbi.nlm.nih.gov/pubmed/26618721 http://dx.doi.org/10.1038/labinvest.2015.144 |