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KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration

Brain neural stem cells (RGPs) undergo a mysterious form of cell cycle-entrained “interkinetic” nuclear migration (INM), driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the consequences of...

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Detalles Bibliográficos
Autores principales: Carabalona, Aurelie, Hu, Daniel Jun-Kit, B. Vallee1, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731285/
https://www.ncbi.nlm.nih.gov/pubmed/26752160
http://dx.doi.org/10.1038/nn.4213