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KIF1A inhibition immortalizes brain stem cells but blocks BDNF-mediated neuronal migration
Brain neural stem cells (RGPs) undergo a mysterious form of cell cycle-entrained “interkinetic” nuclear migration (INM), driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the consequences of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731285/ https://www.ncbi.nlm.nih.gov/pubmed/26752160 http://dx.doi.org/10.1038/nn.4213 |