Cargando…

Neurexin 1 (NRXN1) Splice Isoform Expression During Human Neocortical Development and Aging

Neurexin 1 (NRXN1), a presynaptic adhesion molecule, is implicated in several neurodevelopmental disorders characterized by synaptic dysfunction including, autism, intellectual disability, and schizophrenia. To gain insight into NRXN1’s involvement in human cortical development we used quantitative...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jenkins, Aaron K., Paterson, Clare, Wang, Yanhong, Hyde, Thomas M., Kleinman, Joel E., Law, Amanda J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731316/ https://www.ncbi.nlm.nih.gov/pubmed/26216298 http://dx.doi.org/10.1038/mp.2015.107

Ejemplares similares

Deletions of NRXN1 (Neurexin-1) Predispose to a Wide Spectrum of Developmental Disorders
por: Ching, Michael SL, et al.
Publicado: (2010)

Neuronal impact of patient-specific aberrant NRXN1α splicing
por: Flaherty, Erin, et al.
Publicado: (2019)

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease
por: Hishimoto, Akitoyo, et al.
Publicado: (2019)

Correction to: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease
por: Hishimoto, Akitoyo, et al.
Publicado: (2019)

Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression
por: Rochtus, Anne M., et al.
Publicado: (2019)

The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins
por: Liakath-Ali, Kif, et al.
Publicado: (2021)

Distinct neurexin isoforms cooperate to initiate and maintain foraging activity
por: Bastien, Brandon L., et al.
Publicado: (2023)

Aerobic Exercise Induces Alternative Splicing of Neurexins in Frontal Cortex
por: Innocenzi, Elisa, et al.
Publicado: (2021)

Neurexins
por: Reissner, Carsten, et al.
Publicado: (2013)

Precise Therapeutic Targeting of Distinct NRXN1(+/−) Mutations
por: Fernando, Michael B., et al.
Publicado: (2023)

NRXN1 deletions identified by array comparative genome hybridisation in a clinical case series – further understanding of the relevance of NRXN1 to neurodevelopmental disorders
por: Curran, Sarah, et al.
Publicado: (2013)

Mutation Analysis of the NRXN1 Gene in Autism Spectrum Disorders
por: Onay, H, et al.
Publicado: (2016)

Exonal Elements and Factors Involved in the Depolarization-Induced Alternative Splicing of Neurexin 2
por: Rozic, G., et al.
Publicado: (2012)

Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing
por: Wilson, Steven C, et al.
Publicado: (2019)

Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1
por: Gregor, Anne, et al.
Publicado: (2011)

Functional Impacts of NRXN1 Knockdown on Neurodevelopment in Stem Cell Models
por: Zeng, Liyun, et al.
Publicado: (2013)

NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis
por: Alliey-Rodriguez, Ney, et al.
Publicado: (2019)

Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus
por: Lin, Pei-Yi, et al.
Publicado: (2023)

Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung’s disease
por: Li, Yanhong, et al.
Publicado: (2018)

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus
por: Lloyd, Brian A, et al.
Publicado: (2023)

Advances in neurexin studies and the emerging role of neurexin-2 in autism spectrum disorder
por: Khoja, Sheraz, et al.
Publicado: (2023)

A common cognitive, psychiatric, and dysmorphic phenotype in carriers of NRXN1 deletion
por: Viñas-Jornet, Marina, et al.
Publicado: (2014)

Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice
por: Xu, Bing, et al.
Publicado: (2023)

Neurexin 1 variants as risk factors for suicide death
por: William, Nancy, et al.
Publicado: (2021)

FoxQ1 Promotes Glioma Cells Proliferation and Migration by Regulating NRXN3 Expression
por: Sun, Hong-Tao, et al.
Publicado: (2013)

Is NRXN1 Gene Expression an Important Marker of Treatment of Depressive Disorders? A Pilot Study
por: Skiba, Aleksandra, et al.
Publicado: (2021)

Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization
por: Naito, Yusuke, et al.
Publicado: (2017)

An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus
por: Nguyen, Thi-Minh, et al.
Publicado: (2016)

Neurexins and their ligands at inhibitory synapses
por: Boxer, Emma E., et al.
Publicado: (2022)

Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia
por: Ishizuka, Kanako, et al.
Publicado: (2020)

NRXN1α(+/-) is associated with increased excitability in ASD iPSC-derived neurons
por: Avazzadeh, Sahar, et al.
Publicado: (2021)

Isoform Age - Splice Isoform Profiling Using Long-Read Technologies
por: De Paoli-Iseppi, Ricardo, et al.
Publicado: (2021)

Dynamic Changes in Neurexins' Alternative Splicing: Role of Rho-Associated Protein Kinases and Relevance to Memory Formation
por: Rozic, Gabriela, et al.
Publicado: (2011)

Correction: An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus
por: Nguyen, Thi-Minh, et al.
Publicado: (2017)

Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism
por: Lin, Pei-Yi, et al.
Publicado: (2023)

Heterozygous Deletion of α-Neurexin I or α-Neurexin II Results in Behaviors Relevant to Autism and Schizophrenia
por: Dachtler, James, et al.
Publicado: (2015)

α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization
por: Feller, Benjamin, et al.
Publicado: (2023)

A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population
por: Yue, Weihua, et al.
Publicado: (2011)

Deletion of NRXN1α impairs long-range and local connectivity in amygdala fear circuit
por: Asede, Douglas, et al.
Publicado: (2020)

Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction
por: Alabi, Opeyemi O, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vcjp1g4cnklv44712s2tmfsujs