Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis

Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of the...

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Detalles Bibliográficos
Autores principales: Krueger, Andrew S., Munck, Christian, Dantas, Gautam, Church, George M., Galagan, James, Lehár, Joseph, Sommer, Morten O. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731467/
https://www.ncbi.nlm.nih.gov/pubmed/26821252
http://dx.doi.org/10.1371/journal.pone.0147651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731467/
https://www.ncbi.nlm.nih.gov/pubmed/26821252
http://dx.doi.org/10.1371/journal.pone.0147651

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