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Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis
Flux balance analysis (FBA) is an increasingly useful approach for modeling the behavior of metabolic systems. However, standard FBA modeling of genetic knockouts cannot predict drug combination synergies observed between serial metabolic targets, even though such synergies give rise to some of the...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731467/ https://www.ncbi.nlm.nih.gov/pubmed/26821252 http://dx.doi.org/10.1371/journal.pone.0147651 |