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Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding
Disinhibition caused by Cl(−) dysregulation is implicated in several neurological disorders. This form of disinhibition, which stems primarily from impaired Cl(−) extrusion through the co-transporter KCC2, is typically identified by a depolarizing shift in GABA reversal potential (E(GABA)). Here we...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731508/ https://www.ncbi.nlm.nih.gov/pubmed/26858607 http://dx.doi.org/10.3389/fncel.2015.00516 |