Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain

FCHo1, FCHo2, and SGIP1 are key regulators of clathrin-mediated endocytosis. Their μ homology domains (μHDs) interact with the C-terminal region of an endocytic scaffold protein, Eps15, containing fifteen Asp-Pro-Phe (DPF) motifs. Here, we show that the high-affinity μHD-binding site in Eps15 is a r...

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Detalles Bibliográficos
Autores principales: Shimada, Atsushi, Yamaguchi, Atsuko, Kohda, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731787/
https://www.ncbi.nlm.nih.gov/pubmed/26822536
http://dx.doi.org/10.1038/srep19565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731787/
https://www.ncbi.nlm.nih.gov/pubmed/26822536
http://dx.doi.org/10.1038/srep19565

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