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Structural basis for the recognition of two consecutive mutually interacting DPF motifs by the SGIP1 μ homology domain
FCHo1, FCHo2, and SGIP1 are key regulators of clathrin-mediated endocytosis. Their μ homology domains (μHDs) interact with the C-terminal region of an endocytic scaffold protein, Eps15, containing fifteen Asp-Pro-Phe (DPF) motifs. Here, we show that the high-affinity μHD-binding site in Eps15 is a r...
Autores principales: | Shimada, Atsushi, Yamaguchi, Atsuko, Kohda, Daisuke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731787/ https://www.ncbi.nlm.nih.gov/pubmed/26822536 http://dx.doi.org/10.1038/srep19565 |
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