High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy

BACKGROUND: We tested the hypothesis that glucose-induced hyperosmolarity, occurring in diabetic hyperglycemia, promotes retinal angiogenesis, and that interference with osmolarity signaling ameliorates excessive angiogenesis and retinopathy in vitro and in vivo. METHODS AND RESULTS: We incubated hu...

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Detalles Bibliográficos
Autores principales: Madonna, Rosalinda, Giovannelli, Gaia, Confalone, Pamela, Renna, Francesca Vera, Geng, Yong-Jian, De Caterina, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731895/
https://www.ncbi.nlm.nih.gov/pubmed/26822858
http://dx.doi.org/10.1186/s12933-016-0342-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731895/
https://www.ncbi.nlm.nih.gov/pubmed/26822858
http://dx.doi.org/10.1186/s12933-016-0342-4

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