Timing, rates and spectra of human germline mutation

Germline mutations are a driving force behind genome evolution and genetic disease. We investigated genome-wide mutation rates and spectra in multi-sibling families. Mutation rate increased with paternal age in all families, but the number of additional mutations per year differed more than two-fold...

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Detalles Bibliográficos
Autores principales: Rahbari, Raheleh, Wuster, Arthur, Lindsay, Sarah J., Hardwick, Robert J., Alexandrov, Ludmil B., Turki, Saeed Al, Dominiczak, Anna, Morris, Andrew, Porteous, David, Smith, Blair, Stratton, Michael R., Hurles, Matthew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731925/
https://www.ncbi.nlm.nih.gov/pubmed/26656846
http://dx.doi.org/10.1038/ng.3469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731925/
https://www.ncbi.nlm.nih.gov/pubmed/26656846
http://dx.doi.org/10.1038/ng.3469

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