The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H(2)O(2)-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is an important factor in the pathogenesis of age-related macular degeneration (AMD). Previous studies have shown that RTA 408, a synthetic triterpenoid compound, potently activates Nrf2. This study aimed to investigate the protec...

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Detalles Bibliográficos
Autores principales: Liu, Xiaobin, Ward, Keith, Xavier, Christy, Jann, Jamieson, Clark, Abbot F., Pang, Iok-Hou, Wu, Hongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731949/
https://www.ncbi.nlm.nih.gov/pubmed/26773873
http://dx.doi.org/10.1016/j.redox.2015.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731949/
https://www.ncbi.nlm.nih.gov/pubmed/26773873
http://dx.doi.org/10.1016/j.redox.2015.12.005

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