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High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii

BACKGROUND: Imbalance in cofactors causing the accumulation of intermediates in biosynthesis pathways is a frequently occurring problem in metabolic engineering when optimizing a production pathway in a microorganism. In our previous study, a single knock-out Citrobacter werkmanii ∆dhaD was construc...

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Detalles Bibliográficos
Autores principales:	Maervoet, Veerle E. T., De Maeseneire, Sofie L., Avci, Fatma G., Beauprez, Joeri, Soetaert, Wim K., De Mey, Marjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731958/ https://www.ncbi.nlm.nih.gov/pubmed/26822953 http://dx.doi.org/10.1186/s12934-016-0421-y

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