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Reduced CYFIP1 in Human Neural Progenitors Results in Dysregulation of Schizophrenia and Epilepsy Gene Networks
Deletions encompassing the BP1-2 region at 15q11.2 increase schizophrenia and epilepsy risk, but only some carriers have either disorder. To investigate the role of CYFIP1, a gene within the region, we performed knockdown experiments in human neural progenitors derived from donors with 2 copies of e...
Autores principales: | Nebel, Rebecca A., Zhao, Dejian, Pedrosa, Erika, Kirschen, Jill, Lachman, Herbert M., Zheng, Deyou, Abrahams, Brett S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732616/ https://www.ncbi.nlm.nih.gov/pubmed/26824476 http://dx.doi.org/10.1371/journal.pone.0148039 |
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