Enzymes for Pancreatic Islet Isolation Impact Chemokine-Production and Polarization of Insulin-Producing β-Cells with Reduced Functional Survival of Immunoisolated Rat Islet-Allografts as a Consequence

The primary aim of this study was to determine whether normal variations in enzyme-activities of collagenases applied for rat-islet isolation impact longevity of encapsulated islet grafts. Also we studied the functional and immunological properties of rat islets isolated with different enzyme prepar...

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Detalles Bibliográficos
Autores principales: de Vos, Paul, Smink, Alexandra M., Paredes, Genaro, Lakey, Jonathan R. T., Kuipers, Jeroen, Giepmans, Ben N. G., de Haan, Bart J., Faas, Marijke M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732769/
https://www.ncbi.nlm.nih.gov/pubmed/26824526
http://dx.doi.org/10.1371/journal.pone.0147992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732769/
https://www.ncbi.nlm.nih.gov/pubmed/26824526
http://dx.doi.org/10.1371/journal.pone.0147992

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