Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

Ataxia telangiectasia mutated (ATM) kinase plays a crucial role as a master controller in the cellular DNA damage response. Inhibition of ATM leads to inhibition of the checkpoint signaling pathway. Hence, addition of checkpoint inhibitors to anticancer therapies may be an effective targeting strate...

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Detalles Bibliográficos
Autores principales: Tatewaki, Naoto, Konishi, Tetsuya, Nakajima, Yuki, Nishida, Miyako, Saito, Masafumi, Eitsuka, Takahiro, Sakamaki, Toshiyuki, Ikekawa, Nobuo, Nishida, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732816/
https://www.ncbi.nlm.nih.gov/pubmed/26824362
http://dx.doi.org/10.1371/journal.pone.0147570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732816/
https://www.ncbi.nlm.nih.gov/pubmed/26824362
http://dx.doi.org/10.1371/journal.pone.0147570

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