NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1

The circadian clock controls the transcription of hundred genes through specific chromatin remodeling events. The histone methyltransferase Mixed-Lineage Leukemia 1 (MLL1) coordinates recruitment of CLOCK–BMAL1 activator complexes to chromatin, an event associated to cyclic H3K4 tri-methylation at c...

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Detalles Bibliográficos
Autores principales: Aguilar-Arnal, Lorena, Katada, Sayako, Orozco-Solis, Ricardo, Sassone-Corsi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732879/
https://www.ncbi.nlm.nih.gov/pubmed/25751424
http://dx.doi.org/10.1038/nsmb.2990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732879/
https://www.ncbi.nlm.nih.gov/pubmed/25751424
http://dx.doi.org/10.1038/nsmb.2990

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