Cargando…
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
The circadian clock controls the transcription of hundred genes through specific chromatin remodeling events. The histone methyltransferase Mixed-Lineage Leukemia 1 (MLL1) coordinates recruitment of CLOCK–BMAL1 activator complexes to chromatin, an event associated to cyclic H3K4 tri-methylation at c...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732879/ https://www.ncbi.nlm.nih.gov/pubmed/25751424 http://dx.doi.org/10.1038/nsmb.2990 |