A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation

The ability to precisely modify genomes and regulate specific genes will greatly accelerate several medical and engineering applications. The CRISPR/Cas9 (Type II) system binds and cuts DNA using guide RNAs, though the variables that control its on-target and off-target activity remain poorly charac...

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Detalles Bibliográficos
Autores principales: Farasat, Iman, Salis, Howard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732943/
https://www.ncbi.nlm.nih.gov/pubmed/26824432
http://dx.doi.org/10.1371/journal.pcbi.1004724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732943/
https://www.ncbi.nlm.nih.gov/pubmed/26824432
http://dx.doi.org/10.1371/journal.pcbi.1004724

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