HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

HIV encodes Tat, a small protein that facilitates viral transcription by binding an RNA structure (trans-activating RNA [TAR]) formed on nascent viral pre-messenger RNAs. Besides this well-characterized mechanism, Tat appears to modulate cellular transcription, but the target genes and molecular mec...

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Detalles Bibliográficos
Autores principales: Reeder, Jonathan E, Kwak, Youn-Tae, McNamara, Ryan P, Forst, Christian V, D'Orso, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Genes and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733046/
https://www.ncbi.nlm.nih.gov/pubmed/26488441
http://dx.doi.org/10.7554/eLife.08955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733046/
https://www.ncbi.nlm.nih.gov/pubmed/26488441
http://dx.doi.org/10.7554/eLife.08955

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