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HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

HIV encodes Tat, a small protein that facilitates viral transcription by binding an RNA structure (trans-activating RNA [TAR]) formed on nascent viral pre-messenger RNAs. Besides this well-characterized mechanism, Tat appears to modulate cellular transcription, but the target genes and molecular mec...

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Detalles Bibliográficos
Autores principales:	Reeder, Jonathan E, Kwak, Youn-Tae, McNamara, Ryan P, Forst, Christian V, D'Orso, Iván
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Genes and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733046/ https://www.ncbi.nlm.nih.gov/pubmed/26488441 http://dx.doi.org/10.7554/eLife.08955

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