T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion

MAPK signaling is important for T lymphocyte development, homeostasis, and effector responses. To better understand the role of Mekk1 (encoded by Map3k1) in T cells, we conditionally deleted Map3k1 in Lck(Cre/+)Map3k1(f/f) mice, and these display larger iNKT cell populations within the liver, spleen...

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Detalles Bibliográficos
Autores principales: Suddason, Tesha, Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733086/
https://www.ncbi.nlm.nih.gov/pubmed/26774476
http://dx.doi.org/10.1016/j.celrep.2015.12.047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733086/
https://www.ncbi.nlm.nih.gov/pubmed/26774476
http://dx.doi.org/10.1016/j.celrep.2015.12.047

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