T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion

MAPK signaling is important for T lymphocyte development, homeostasis, and effector responses. To better understand the role of Mekk1 (encoded by Map3k1) in T cells, we conditionally deleted Map3k1 in Lck(Cre/+)Map3k1(f/f) mice, and these display larger iNKT cell populations within the liver, spleen...

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Autores principales: Suddason, Tesha, Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733086/
https://www.ncbi.nlm.nih.gov/pubmed/26774476
http://dx.doi.org/10.1016/j.celrep.2015.12.047
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author Suddason, Tesha
Anwar, Saba
Charlaftis, Nikolaos
Gallagher, Ewen
author_facet Suddason, Tesha
Anwar, Saba
Charlaftis, Nikolaos
Gallagher, Ewen
author_sort Suddason, Tesha
collection PubMed
description MAPK signaling is important for T lymphocyte development, homeostasis, and effector responses. To better understand the role of Mekk1 (encoded by Map3k1) in T cells, we conditionally deleted Map3k1 in Lck(Cre/+)Map3k1(f/f) mice, and these display larger iNKT cell populations within the liver, spleen, and bone marrow. Mekk1 signaling controls splenic and liver iNKT cell expansion in response to glycolipid antigen. Lck(Cre/+)Map3k1(f/f) mice have enhanced liver damage in response to glycolipid antigen. Mekk1 regulates Jnk activation in iNKT cells and binds and transfers Lys63-linked poly-ubiquitin onto Carma1. Map3k1 is critical for the regulation of p27(Kip1) (encoded by Cdkn1b).
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spelling pubmed-47330862016-02-26 T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion Suddason, Tesha Anwar, Saba Charlaftis, Nikolaos Gallagher, Ewen Cell Rep Report MAPK signaling is important for T lymphocyte development, homeostasis, and effector responses. To better understand the role of Mekk1 (encoded by Map3k1) in T cells, we conditionally deleted Map3k1 in Lck(Cre/+)Map3k1(f/f) mice, and these display larger iNKT cell populations within the liver, spleen, and bone marrow. Mekk1 signaling controls splenic and liver iNKT cell expansion in response to glycolipid antigen. Lck(Cre/+)Map3k1(f/f) mice have enhanced liver damage in response to glycolipid antigen. Mekk1 regulates Jnk activation in iNKT cells and binds and transfers Lys63-linked poly-ubiquitin onto Carma1. Map3k1 is critical for the regulation of p27(Kip1) (encoded by Cdkn1b). Cell Press 2016-01-07 /pmc/articles/PMC4733086/ /pubmed/26774476 http://dx.doi.org/10.1016/j.celrep.2015.12.047 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Report
Suddason, Tesha
Anwar, Saba
Charlaftis, Nikolaos
Gallagher, Ewen
T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion
title T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion
title_full T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion
title_fullStr T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion
title_full_unstemmed T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion
title_short T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion
title_sort t-cell-specific deletion of map3k1 reveals the critical role for mekk1 and jnks in cdkn1b-dependent proliferative expansion
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733086/
https://www.ncbi.nlm.nih.gov/pubmed/26774476
http://dx.doi.org/10.1016/j.celrep.2015.12.047
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