Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the classic and most widely used drugs is pentamidine, an aromatic diamidine compound introduced in the 1940s. Recently, a genome-wide loss-of-fun...

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Detalles Bibliográficos
Autores principales: Song, Jie, Baker, Nicola, Rothert, Monja, Henke, Björn, Jeacock, Laura, Horn, David, Beitz, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734766/
https://www.ncbi.nlm.nih.gov/pubmed/26828608
http://dx.doi.org/10.1371/journal.ppat.1005436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734766/
https://www.ncbi.nlm.nih.gov/pubmed/26828608
http://dx.doi.org/10.1371/journal.ppat.1005436

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