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Quantifying Clonal and Subclonal Passenger Mutations in Cancer Evolution
The vast majority of mutations in the exome of cancer cells are passengers, which do not affect the reproductive rate of the cell. Passengers can provide important information about the evolutionary history of an individual cancer, and serve as a molecular clock. Passengers can also become targets f...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734774/ https://www.ncbi.nlm.nih.gov/pubmed/26828429 http://dx.doi.org/10.1371/journal.pcbi.1004731 |