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Detection of AR-V7 mRNA in whole blood may not predict the effectiveness of novel endocrine drugs for castration-resistant prostate cancer

A splice variant of androgen receptor (AR), AR-V7, lacks in androgen-binding portion and leads to aggressive cancer characteristics. Reverse transcription-polymerase chain reactions (PCRs) and subsequent nested PCRs for the amplification of AR-V7 and prostate-specific antigen (PSA) transcripts were...

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Detalles Bibliográficos
Autores principales: Takeuchi, Takumi, Okuno, Yumiko, Hattori-Kato, Mami, Zaitsu, Masayoshi, Mikami, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734820/
https://www.ncbi.nlm.nih.gov/pubmed/26870716
http://dx.doi.org/10.2147/RRU.S98877