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Combined local and systemic immunization is essential for durable T-cell mediated heterosubtypic immunity against influenza A virus
The threat from unpredictable influenza virus pandemics necessitates the development of a new type of influenza vaccine. Since the internal proteins are highly conserved, induction of T cells targeting these antigens may provide the solution. Indeed, adenoviral (Ad) vectors expressing flu nucleoprot...
Autores principales: | Uddback, Ida E. M., Pedersen, Line M. I., Pedersen, Sara R., Steffensen, Maria A., Holst, Peter J., Thomsen, Allan R., Christensen, Jan P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735591/ https://www.ncbi.nlm.nih.gov/pubmed/26831578 http://dx.doi.org/10.1038/srep20137 |
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