New observations on maternal age effect on germline de novo mutations

Germline mutations are the source of evolution and contribute substantially to many health-related processes. Here we use whole-genome deep sequencing data from 693 parents–offspring trios to examine the de novo point mutations (DNMs) in the offspring. Our estimate for the mutation rate per base pai...

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Detalles Bibliográficos
Autores principales: Wong, Wendy S. W., Solomon, Benjamin D., Bodian, Dale L., Kothiyal, Prachi, Eley, Greg, Huddleston, Kathi C., Baker, Robin, Thach, Dzung C., Iyer, Ramaswamy K., Vockley, Joseph G., Niederhuber, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735694/
https://www.ncbi.nlm.nih.gov/pubmed/26781218
http://dx.doi.org/10.1038/ncomms10486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735694/
https://www.ncbi.nlm.nih.gov/pubmed/26781218
http://dx.doi.org/10.1038/ncomms10486

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