The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42

Regulation of Shp2, a tyrosine phosphatase, critically influences the development of various diseases. Its role in epithelial lumenogenesis is not clear. Here we show that oncogenic Shp2 dephosphorylates Tuba to decrease Cdc42 activation, leading to the abnormal multi-lumen formation of epithelial c...

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Detalles Bibliográficos
Autores principales: Tien, Sui-Chih, Lee, Hsiao-Hui, Yang, Ya-Chi, Lin, Miao-Hsia, Chen, Yu-Ju, Chang, Zee-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735695/
https://www.ncbi.nlm.nih.gov/pubmed/26783207
http://dx.doi.org/10.1038/ncomms10420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735695/
https://www.ncbi.nlm.nih.gov/pubmed/26783207
http://dx.doi.org/10.1038/ncomms10420

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