Protein unfolding as a switch from self-recognition to high-affinity client binding

Stress-specific activation of the chaperone Hsp33 requires the unfolding of a central linker region. This activation mechanism suggests an intriguing functional relationship between the chaperone's own partial unfolding and its ability to bind other partially folded client proteins. However, id...

Descripción completa

Detalles Bibliográficos
Autores principales: Groitl, Bastian, Horowitz, Scott, Makepeace, Karl A. T., Petrotchenko, Evgeniy V., Borchers, Christoph H., Reichmann, Dana, Bardwell, James C. A., Jakob, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735815/
https://www.ncbi.nlm.nih.gov/pubmed/26787517
http://dx.doi.org/10.1038/ncomms10357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735815/
https://www.ncbi.nlm.nih.gov/pubmed/26787517
http://dx.doi.org/10.1038/ncomms10357

Ejemplares similares