Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

Mechanosensitive ion channels are force-transducing enzymes that couple mechanical stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is challenging because the stimulus seen by the channel reflects forces shared between the membrane, cytoskeleton and extracellular...

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Detalles Bibliográficos
Autores principales: Cox, Charles D., Bae, Chilman, Ziegler, Lynn, Hartley, Silas, Nikolova-Krstevski, Vesna, Rohde, Paul R., Ng, Chai-Ann, Sachs, Frederick, Gottlieb, Philip A., Martinac, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735864/
https://www.ncbi.nlm.nih.gov/pubmed/26785635
http://dx.doi.org/10.1038/ncomms10366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735864/
https://www.ncbi.nlm.nih.gov/pubmed/26785635
http://dx.doi.org/10.1038/ncomms10366

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