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Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
Mechanosensitive ion channels are force-transducing enzymes that couple mechanical stimuli to ion flux. Understanding the gating mechanism of mechanosensitive channels is challenging because the stimulus seen by the channel reflects forces shared between the membrane, cytoskeleton and extracellular...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735864/ https://www.ncbi.nlm.nih.gov/pubmed/26785635 http://dx.doi.org/10.1038/ncomms10366 |