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Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
BACKGROUND: Nur77, a key member of the NR4A receptor subfamily, is involved in the regulation of inflammation and immunity. However, the in vivo regulatory roles of Nur77 in sepsis and the mechanisms involved remains largely elusive. In this study, we used Nur77-deficient (Nur77(−/−)) mice and inves...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735956/ https://www.ncbi.nlm.nih.gov/pubmed/26839514 http://dx.doi.org/10.1186/s12950-016-0112-9 |