Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation

BACKGROUND: Efavirenz, widely used as part of antiretroviral drug regimens in the treatment of paediatric human immunodeficiency virus infection, has central nervous system side effects. We describe four children presenting with serious, persistent central nervous system adverse events who were foun...

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Detalles Bibliográficos
Autores principales: Pinillos, Francoise, Dandara, Collet, Swart, Marelize, Strehlau, Renate, Kuhn, Louise, Patel, Faeezah, Coovadia, Ashraf, Abrams, Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735961/
https://www.ncbi.nlm.nih.gov/pubmed/26831894
http://dx.doi.org/10.1186/s12879-016-1381-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735961/
https://www.ncbi.nlm.nih.gov/pubmed/26831894
http://dx.doi.org/10.1186/s12879-016-1381-x

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