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Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization

The hexokinase 1 variant in mammalian spermatozoa (HK1S) has a unique N-terminus and this isoform atypically localizes to the plasma membrane. However, the mechanism of this process currently remains ambiguous. In this report, we show that fatty acylation underlies the specific sorting of HK1S. Empl...

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Detalles Bibliográficos
Autores principales: Kumar, Sujeet, Parameswaran, Sreejit, Sharma, Rajendra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736023/
https://www.ncbi.nlm.nih.gov/pubmed/26581589
http://dx.doi.org/10.1242/bio.012831