S phase block following MEC1(ATR) inactivation occurs without severe dNTP depletion

Inactivation of Mec1, the budding yeast ATR, results in a permanent S phase arrest followed by chromosome breakage and cell death during G2/M. The S phase arrest is proposed to stem from a defect in Mec1-mediated degradation of Sml1, a conserved inhibitor of ribonucleotide reductase (RNR), causing a...

Descripción completa

Detalles Bibliográficos
Autores principales: Earp, Caroline, Rowbotham, Samuel, Merényi, Gábor, Chabes, Andrei, Cha, Rita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736042/
https://www.ncbi.nlm.nih.gov/pubmed/26603472
http://dx.doi.org/10.1242/bio.015347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736042/
https://www.ncbi.nlm.nih.gov/pubmed/26603472
http://dx.doi.org/10.1242/bio.015347

Ejemplares similares