Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

The phosphorylation cascade in the extracellular signal-regulated kinase (ERK) pathway is a versatile reaction network motif that can potentially act as a switch, oscillator or memory. Nevertheless, there is accumulating evidence that the phosphorylation response is mostly linear to extracellular si...

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Detalles Bibliográficos
Autores principales: Shindo, Yuki, Iwamoto, Kazunari, Mouri, Kazunari, Hibino, Kayo, Tomita, Masaru, Kosako, Hidetaka, Sako, Yasushi, Takahashi, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736105/
https://www.ncbi.nlm.nih.gov/pubmed/26786866
http://dx.doi.org/10.1038/ncomms10485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736105/
https://www.ncbi.nlm.nih.gov/pubmed/26786866
http://dx.doi.org/10.1038/ncomms10485

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