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Neuroprotective Transcription Factors in Animal Models of Parkinson Disease

A number of transcription factors, including En1/2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3, with key roles in midbrain dopaminergic (mDA) neuron development, also regulate adult mDA neuron survival and physiology. Mouse models with targeted disruption of some of these genes display several feature...

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Detalles Bibliográficos
Autores principales: Blaudin de Thé, François-Xavier, Rekaik, Hocine, Prochiantz, Alain, Fuchs, Julia, Joshi, Rajiv L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736191/
https://www.ncbi.nlm.nih.gov/pubmed/26881122
http://dx.doi.org/10.1155/2016/6097107